scleroderma

Kuongorora kwe scleroderma

Scleroderma chirwere che autoimmune connective tissue chirwere uye rheumatic chirwere chinokonzera kuzvimba kweganda nedzimwe nzvimbo dzemuviri. Kana immune system ikaita kuti matishu afunge kuti akakuvadzwa, zvinokonzeresa kuzvimba uye muviri unoburitsa yakawandisa collagen, zvichitungamira kune scleroderma. Yakawandisa collagen muganda uye mamwe matissue zvinoguma nemapatch eganda rakaoma uye rakaomarara. Scleroderma inokanganisa masisitimu mazhinji mumuviri wako. Tsanangudzo dzinotevera dzichakubatsira kuti unzwisise zviri nani kuti chirwere ichi chinokanganisa sei chimwe nechimwe chezvirongwa izvi.

• Connective tissue disease chirwere chinokanganisa matishu akadai seganda, tendon, uye cartilage. Connective tishu inotsigira, inodzivirira, uye inopa chimiro kune mamwe matishu uye nhengo.
• Zvirwere zve autoimmune zvinoitika apo immune system, iyo inowanzo batsira kudzivirira muviri kubva kuhutachiona uye chirwere, ichirwisa matishu ayo.
• Rheumatic zvirwere zvinoreva boka remamiriro ezvinhu anoonekwa nekuzvimba kana kurwadziwa kwemhasuru, majoini kana fibrous tissue.

Kune marudzi maviri makuru e scleroderma:

• Localized scleroderma inongobata ganda uye zvimiro zvakananga pasi peganda.
• Systemic scleroderma, inonziwo systemic sclerosis, inokanganisa masisitimu mazhinji emuviri. Iyi imhando yakakomba yescleroderma inogona kukuvadza tsinga dzeropa uye nhengo dzemukati dzakadai semoyo, mapapu, uye itsvo.

Iko hakuna mushonga we scleroderma. Chinangwa chekurapa ndechekubvisa zviratidzo uye kumisa kufambira mberi kwechirwere. Kukurumidza kuongororwa uye kuongororwa kunoramba kuripo kwakakosha.

Chii chinoitika ne scleroderma?

Chikonzero che scleroderma hachizivikanwi. Zvisinei, vatsvakurudzi vanodavira kuti masoja emumuviri anodzivirira zvirwere anowanda uye anokonzeresa kuzvimba uye kukuvadzwa kwemasero ari mutsinga dzeropa. Izvi zvinokonzeresa masero ematishu anobatanidza, kunyanya sero remhando inonzi fibroblasts, kuburitsa yakawandisa collagen nemamwe mapuroteni. Fibroblasts inorarama kwenguva yakareba kupfuura yakajairwa, zvichiita kuti collagen iwande muganda uye dzimwe nhengo, zvichitungamira kune zviratidzo nezviratidzo zve scleroderma.

Ndiani ane scleroderma?

Munhu wose anogona kuwana scleroderma; zvisinei, mamwe mapoka ane ngozi huru yekubata hosha. Zvinhu zvinotevera zvinogona kukanganisa njodzi yako.

• Bonde. Scleroderma inowanzoitika muvakadzi kupfuura varume.
• Age. Chirwere ichi chinowanzoonekwa pakati pemakore 30 ne50 uye chinowanzoitika kune vanhu vakuru kupfuura vana.
• Race. Scleroderma inogona kubata vanhu vemarudzi ese nemadzinza, asi chirwere ichi chinogona kubata maAfrica America zvakanyanya. Semuyenzaniso: 
  • Chirwere ichi chinowanikwa muAfrica America kupfuura muEurope America.
  • Vanhu vemuAfrica vekuAmerica vane scleroderma vanokura chirwere ichi kare zvichienzaniswa nemamwe mapoka.
  • Vanhu veAfrica vekuAmerica vanowanzoita maronda eganda uye chirwere chemapapu zvichienzaniswa nemamwe mapoka.

Mhando dze scleroderma

• Localized scleroderma inokanganisa ganda uye matishu ari pasi uye kazhinji inopa imwe kana maviri emhando dzinotevera:
  • Morpheus kana scleroderma patches, iyo inogona kuva hafu ye inch kana kupfuura muhupamhi.
  • Linear scleroderma ndiyo apo kukora kwescleroderma kunoitika mumutsara. Inowanzopararira pasi ruoko kana gumbo, asi dzimwe nguva inopararira pamusoro pehuma uye chiso.
• Systemic scleroderma, dzimwe nguva inonzi systemic sclerosis, inokanganisa ganda, matishu, tsinga dzeropa, uye nhengo huru. Vanachiremba vanowanzo patsanura systemic scleroderma mumhando mbiri:
  • Limited cutaneous scleroderma inokura zvishoma nezvishoma uye inokanganisa ganda rezvigunwe, maoko, kumeso, maoko, uye makumbo pasi pemabvi.
  • Inopararira cutaneous scleroderma inokura nekukurumidza uye inotanga nezvigunwe nezvigunwe, asi inopararira kupfuura magokora nemabvi kusvika pamapendekete, hunde, uye muhudyu. Rudzi urwu runowanzova nekukuvara kwakanyanya kune nhengo dzemukati.  

Zviratidzo zve scleroderma

Zviratidzo zve scleroderma zvinosiyana pamunhu nemunhu zvichienderana nerudzi rwe scleroderma.

Localized scleroderma inowanzokonzera zvigamba zveganda gobvu, rakaomarara mune imwe yemhando mbiri.

• Morphea inokonzera kukora kwezvigamba zveganda kuita zvigamba zvakaomarara zvakaita seovhari. Nzvimbo idzi dzinogona kunge dziine yero, ine waxy chitarisiko chakakomberedzwa nedzvuku kana dzvuku. Mavara anogona kuramba ari munzvimbo imwe kana kupararira kune dzimwe nzvimbo dzeganda. Chirwere chinowanzoita chisingaiti nekufamba kwenguva, asi iwe unogona kunge uchine rima reganda. Vamwe vanhu vanotangawo kuneta (kunzwa kuneta).
• Mune linear scleroderma, mitsetse yeganda rakakora kana ruvara rinodzika neruoko, gumbo, uye, kashoma, pahuma.

Systemic scleroderma, inozivikanwawo se systemic sclerosis, inogona kukura nekukurumidza kana zvishoma nezvishoma uye inogona kukonzera matambudziko kwete neganda chete asiwo nenhengo dzemukati. Vanhu vazhinji vane rudzi urwu rwescleroderma vanonzwa kuneta.

• Localized cutaneous scleroderma inokura zvishoma nezvishoma uye kazhinji inobata ganda paminwe, maoko, chiso, maoko, uye makumbo pasi pemabvi. Inogonawo kukonzera matambudziko netsinga dzeropa uye esophagus. Iyo yakaganhurirwa fomu ine visceral kubatanidzwa asi kazhinji yakapfava pane inopararira fomu. Vanhu vane localized cutaneous scleroderma kazhinji vane zvese kana zvimwe zvezviratidzo, izvo zvinonzi nevamwe vanachiremba seCREST, zvinoreva zvinotevera zviratidzo:
  • Calcification, kuumbwa kwekarusiyamu inoisa muhutano hunobatanidza, iyo inogona kuonekwa ne X-ray kuongorora.
  • Raynaud's phenomenon, mamiriro ezvinhu apo tsinga duku dzeropa mumaoko kana tsoka dzinopindirana nekuda kwechando kana kufunganya, zvichiita kuti zvigunwe uye zvigunwe zvishandure ruvara (chena, bhuruu, uye / kana tsvuku).
  • Kusashanda zvakanaka kwegurokuro, kunoreva kusashanda zvakanaka kwegurokuro (chubhu inobatanidza huro nedumbu) kunoitika apo tsandanyama dzegurokuro dzinotadza kufamba zvakanaka.
  • Sclerodactyly gobvu uye gobvu ganda pazvigunwe zvichibva mukuiswa kweiyo collagen yakawandisa muzvikamu zveganda.
  • Telangiectasia, chirwere chinokonzerwa nekuzvimba kwetsinga diki dzeropa izvo zvinoita kuti makwapa matsvuku aoneke pamaoko nekumeso.
• Diffuse cutaneous scleroderma inoitika kamwe kamwe, kazhinji nekukora kweganda pazvigunwe kana zvigunwe. Kukora kweganda rinobva raenda kumuviri wese pamusoro pemagokora uye/kana mabvi. Mhando iyi inogona kukuvadza nhengo dzako dzemukati se:
  • Chero kupi zvako mune yako digestive system.
  • mapapu ako.
  • itsvo dzako.
  • Mwoyo wako.

Kunyange zvazvo CREST yakambonzi localized scleroderma, vanhu vane diffuse scleroderma vanogonawo kuva nezviratidzo zveCREST.

Zvikonzero zve scleroderma

Vatsvakurudzi havazivi chikonzero chaicho che scleroderma, asi vanofungidzira kuti zvinhu zvakawanda zvingave zvichikonzera mamiriro acho ezvinhu:

• genetic composition. Majini anogona kuwedzera mukana wevamwe vanhu vanogadzira scleroderma uye kuita basa mukuona rudzi rwe scleroderma yavanayo. Iwe haugone kugara nhaka chirwere ichi, uye hachipfuudzwa kubva kumubereki kuenda kumwana senge zvimwe zvirwere zvemajini. Zvisinei, nhengo dzemhuri dzepedyo dzevanhu vane scleroderma dziri panjodzi huru yekubatwa nescleroderma kupfuura huwandu hwevanhu.
• Zvakatipoteredza. Vatsvakurudzi vanofungidzira kuti kutarisana nezvimwe zvinhu zvakatipoteredza, zvakadai sevhairasi kana makemikari, zvinogona kukonzera scleroderma.
• Immune system inoshanduka. Kusajairika kwekudzivirira kana kuzvimba kuita mumuviri wako kunokonzera shanduko dzemaserura dzinokonzera yakawandisa collagen kuburitswa.
• Mahomoni. Vakadzi vanowana mhando dzakawanda dzescleroderma kakawanda kupfuura varume. Vatsvakurudzi vanofungidzira kuti kusiyana kwehomoni pakati pevakadzi nevarume kunogona kuita basa muchirwere.